LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population.

ABSTRACT:

Purpose

We performed genetic association studies using a native Japanese population to examine the reproducibility of results of lysyl oxidase-like 1 (LOXL1) genetic association studies for exfoliation glaucoma (XFG) beyond the differences of ethnicity. We also quantified LOXL1 mRNA expression in the human lens capsule to examine the possible correlation between LOXL1 expression and XFG pathogenesis.

Methods

We performed a case-control study using 95 Japanese XFG patients and 190 controls. Real-time polymerase chain reaction (PCR) analysis was performed using lens capsules obtained during surgery.

Results

The TT genotype in the single nucleotide polymorphism (SNP) rs1048661 and the GG genotype in the SNP rs3825942 in exon 1 of LOXL1 were significantly associated with

SUBMITTER: Mori K 

PROVIDER: S-EPMC2426718 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature