Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension.

ABSTRACT:

Rationale

Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction.

Objectives

We sought to determine if hyponatremia is associated with right heart failure and worse prognosis in patients with pulmonary arterial hypertension (PAH).

Methods

We prospectively followed 40 patients with PAH and examined the relationship between serum sodium and right heart function as well as survival.

Measurements and main results

Subjects with hyponatremia (Na < or = 136 mEq/L) were more symptomatic (11/13 World Health Organization [WHO] class III/IV vs. 12/27 WHO class III/IV; P = 0.02), had more peripheral edema (69 vs. 26%; P = 0.009), and had higher hospitalization rates (85 vs. 41%; P = 0.009) than

SUBMITTER: Forfia PR 

PROVIDER: S-EPMC2427057 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature