A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions.

ABSTRACT: Predictive genomic profiling used to produce personalized nutrition and other lifestyle health recommendations is currently offered directly to consumers. By examining previous meta-analyses and HuGE reviews, we assessed the scientific evidence supporting the purported gene-disease associations for genes included in genomic profiles offered online. We identified seven companies that offer predictive genomic profiling. We searched PubMed for meta-analyses and HuGE reviews of studies of gene-disease associations published from 2000 through June 2007 in which the genotypes of people with a disease were compared with those of a healthy or general-population control group. The seven companies tested at least 69 different polymorphisms in 56 genes. Of the 56 genes tested, 24 (43%) were not revie

SUBMITTER: Janssens AC 

PROVIDER: S-EPMC2427295 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature