A unified association analysis approach for family and unrelated samples correcting for stratification.

ABSTRACT: There are two common designs for association mapping of complex diseases: case-control and family-based designs. A case-control sample is more powerful to detect genetic effects than a family-based sample that contains the same numbers of affected and unaffected persons, although additional markers may be required to control for spurious association. When family and unrelated samples are available, statistical analyses are often performed in the family and unrelated samples separately, conditioning on parental information for the former, thus resulting in reduced power. In this report, we propose a unified approach that can incorporate both family and case-control samples and, provided the additional markers are available, at the same time corrects for population stratification. We apply t

SUBMITTER: Zhu X 

PROVIDER: S-EPMC2427300 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature