Regulation of glycan structures in animal tissues: transcript profiling of glycan-related genes.

ABSTRACT: Glycan structures covalently attached to proteins and lipids play numerous roles in mammalian cells, including protein folding, targeting, recognition, and adhesion at the molecular or cellular level. Regulating the abundance of glycan structures on cellular glycoproteins and glycolipids is a complex process that depends on numerous factors. Most models for glycan regulation hypothesize that transcriptional control of the enzymes involved in glycan synthesis, modification, and catabolism determines glycan abundance and diversity. However, few broad-based studies have examined correlations between glycan structures and transcripts encoding the relevant biosynthetic and catabolic enzymes. Low transcript abundance for many glycan-related genes has hampered broad-based transcript profiling for

SUBMITTER: Nairn AV 

PROVIDER: S-EPMC2427342 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature