Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer.

ABSTRACT:

Background

A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed that BCL2 protein expression had prognostic power independent of current used standards. Here, we present the results of a meta-analysis of the association between BCL2 expression and both disease free survival (DFS) and overall survival (OS) in female breast cancer.

Methods

Reports published in 1994-2006 were selected for the meta-analysis using a search of PubMed. Studies that investigated the role of BCL2 expression by immunohistochemistry with a sample size greater than 100 were included. Seventeen papers reported the results of 18 different series inclu

SUBMITTER: Callagy GM 

PROVIDER: S-EPMC2430210 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature