Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.

ABSTRACT: Epidemiological and prospective studies indicate that comprehensive lifestyle changes may modify the progression of prostate cancer. However, the molecular mechanisms by which improvements in diet and lifestyle might affect the prostate microenvironment are poorly understood. We conducted a pilot study to examine changes in prostate gene expression in a unique population of men with low-risk prostate cancer who declined immediate surgery, hormonal therapy, or radiation and participated in an intensive nutrition and lifestyle intervention while undergoing careful surveillance for tumor progression. Consistent with previous studies, significant improvements in weight, abdominal obesity, blood pressure, and lipid profile were observed (all P < 0.05), and surveillance of low-risk patients was

SUBMITTER: Ornish D 

PROVIDER: S-EPMC2430265 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature