Functional integration across a gradient of corticostriatal channels controls UP state transitions in the dorsal striatum.

ABSTRACT: Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome of such spiraling remains to be identified. Here, we examined whether plateau depolarizations (UP states) in striatal neurons relate better to active epochs in local field potentials recorded from closely related cortical areas than to those recorded in less-related cortical areas. Our results show that, in anesthetized rats, the coordination between cortical areas and striatal regions obeys a mediolateral gradient and keeps track of slow wave trajectory across the neocortex. Moreov

SUBMITTER: Kasanetz F 

PROVIDER: S-EPMC2430370 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature