Mesenchymal stem cells in early entry of breast cancer into bone marrow.

ABSTRACT:

Background

An understanding of BC cell (BCC) entry into bone marrow (BM) at low tumor burden is limited when compared to highly metastatic events during heavy tumor burden. BCCs can achieve quiescence, without interfering with hematopoiesis. This occurs partly through the generation of gap junctions with BM stroma, located close to the endosteum. These events are partly mediated by the evolutionary conserved gene, Tac1.

Methodology/principal findings

This study focuses on the role of mesenchymal stem cells (MSCs), Tac1, SDF-1 and CXCR4 in BCC entry into BM. The model is established in studies with low numbers of tumor cells, and focuses on cancer cells with low metastatic and invasion potential. This allowed us to recapitulate early event, and to study cancer cells with low

SUBMITTER: Corcoran KE 

PROVIDER: S-EPMC2430536 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature