Ontology highlight
ABSTRACT:
SUBMITTER: Tombola F
PROVIDER: S-EPMC2430592 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Tombola Francesco F Ulbrich Maximilian H MH Isacoff Ehud Y EY
Neuron 20080501 4
In voltage-gated channels, ions flow through a single pore located at the interface between membrane-spanning pore domains from each of four subunits, and the gates of the pore are controlled by four peripheral voltage-sensing domains. In a striking exception, the newly discovered voltage-gated Hv1 proton channels lack a homologous pore domain, leaving the location of the pore unknown. Also unknown are the number of subunits and the mechanism of gating. We find that Hv1 is a dimer and that each ...[more]