Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

ABSTRACT:

Context

Smoking remains a major public health problem. Twin studies indicate that the ability to quit smoking is substantially heritable, with genetics that overlap modestly with the genetics of vulnerability to dependence on addictive substances.

Objectives

To identify replicated genes that facilitate smokers' abilities to achieve and sustain abstinence from smoking (herein after referred to as quit-success genes) found in more than 2 genome-wide association (GWA) studies of successful vs unsuccessful abstainers, and, secondarily, to nominate genes for selective involvement in smoking cessation success with bupropion hydrochloride vs nicotine replacement therapy (NRT).

Design

The GWA results in subjects from 3 centers, with secondary analyses of NRT vs bupropion resp

SUBMITTER: Uhl GR 

PROVIDER: S-EPMC2430596 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature