Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate.

ABSTRACT:

Background

Epidemiological studies suggest that people who consume more than one portion of cruciferous vegetables per week are at lower risk of both the incidence of prostate cancer and of developing aggressive prostate cancer but there is little understanding of the underlying mechanisms. In this study, we quantify and interpret changes in global gene expression patterns in the human prostate gland before, during and after a 12 month broccoli-rich diet.

Methods and findings

Volunteers were randomly assigned to either a broccoli-rich or a pea-rich diet. After six months there were no differences in gene expression between glutathione S-transferase mu 1 (GSTM1) positive and null individuals on the pea-rich diet but significant differences between GSTM1 genotypes on the brocc

SUBMITTER: Traka M 

PROVIDER: S-EPMC2430620 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature