The tachykinin receptor 3 is associated with alcohol and cocaine dependence.

ABSTRACT:

Background

A broad region on chromosome 4q was previously linked to the phenotype of alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. A strong positional candidate gene was identified within this region: tachykinin receptor 3 gene (TACR3), which encodes tachykinin receptor 3 (NK3R), the receptor for the tachykinin 3 (neurokinin B) peptide. Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of alcohol and NK3R can also mediate the acute and chronic behavioral effects of cocaine.

Methods

Thirty SNPs were genotyped throughout TACR3. Family based association analysis was performed in 219 European American families to detect an association with alcohol dependence. Subsequent analyses wer

SUBMITTER: Foroud T 

PROVIDER: S-EPMC2430628 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature