The fetal origins of memory: the role of dietary choline in optimal brain development.

ABSTRACT: Fetal nutrition sets the stage for organ function in later life. In this review we discuss the fetal and neonatal origins of brain function. Numerous research observations point to the importance of choline for the developing fetus and neonate. This essential nutrient is involved in 1-carbon metabolism and is the precursor for many important compounds, including phospholipids, acetylcholine, and the methyl donor betaine. Dietary intake of choline by the pregnant mother and later by the infant directly affects brain development and results in permanent changes in brain function. In rodents, perinatal supplementation of choline enhances memory and learning functions, changes that endure across the lifespan. Conversely, choline deficiency during these sensitive periods results in memory and c

SUBMITTER: Zeisel SH 

PROVIDER: S-EPMC2430654 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature