Cloning, characterization, and expression of microRNAs from the Asian malaria mosquito, Anopheles stephensi.

ABSTRACT:

Background

microRNAs (miRNAs) are non-coding RNAs that are now recognized as a major class of gene-regulating molecules widely distributed in metozoans and plants. miRNAs have been found to play important roles in apoptosis, cancer, development, differentiation, inflammation, longevity, and viral infection. There are a few reports describing miRNAs in the African malaria mosquito, Anopheles gambiae, on the basis of similarity to known miRNAs from other species. An. stephensi is the most important malaria vector in Asia and it is becoming a model Anopheline species for physiological and genetics studies.

Results

We report the cloning and characterization of 27 distinct miRNAs from 17-day old An. stephensi female mosquitoes. Seventeen of the 27 miRNAs matched previously predic

SUBMITTER: Mead EA 

PROVIDER: S-EPMC2430712 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature