Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.

ABSTRACT:

Objective

To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis.

Methods

Analysis of clinical features, neuropathological findings, tumors, and serum/cerebrospinal fluid antibodies using rat tissue, neuronal cultures, and HEK293 cells expressing subunits of the N-methyl-D-aspartate receptor (NMDAR).

Results

Twelve women (14-44 years) developed prominent psychiatric symptoms, amnesia, seizures, frequent dyskinesias, autonomic dysfunction, and decreased level of consciousness often requiring ventilatory support. All had serum/cerebrospinal fluid antibodies that predominantly immunolabeled the neuropil of hippocampus/forebrain, in particular the cell surface of hippocampal neurons, and reacted with NR2B (and to a lesser extent N

SUBMITTER: Dalmau J 

PROVIDER: S-EPMC2430743 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature