Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies.

ABSTRACT:

Background

The Framingham Heart Study (FHS) recently obtained initial results from the first genome-wide association scan for renal traits. The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples.

Methods

Sixteen SNPs were selected for replication based on the most promising associations with chronic kidney disease (CKD), estimated glomerular filtration rate (eGFR), and serum cystatin C in FHS. These SNPs were genotyped in 15,747 participants of the Atherosclerosis in Communities (ARIC) Study and evaluated for association using multivariable adjusted regression analyses. Primary outcomes in ARIC were CKD and eGFR. Se

SUBMITTER: Kottgen A 

PROVIDER: S-EPMC2430944 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature