Mathematical modeling and analysis of insulin clearance in vivo.

ABSTRACT:

Background

Analyzing the dynamics of insulin concentration in the blood is necessary for a comprehensive understanding of the effects of insulin in vivo. Insulin removal from the blood has been addressed in many studies. The results are highly variable with respect to insulin clearance and the relative contributions of hepatic and renal insulin degradation.

Results

We present a dynamic mathematical model of insulin concentration in the blood and of insulin receptor activation in hepatocytes. The model describes renal and hepatic insulin degradation, pancreatic insulin secretion and nonspecific insulin binding in the liver. Hepatic insulin receptor activation by insulin binding, receptor internalization and autophosphorylation is explicitly included in the model. We present a

SUBMITTER: Koschorreck M 

PROVIDER: S-EPMC2430945 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature