Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway.

ABSTRACT:

Background

The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor alpha (ERalpha) pathway. Among these it was shown that GATA3 associates with the promoter of the ERalpha gene and ERalpha can reciprocally associate with the GATA3 gene. GATA3 has also been directly implicated in a differentiated phenotype in mouse models of mammary tumourigenesis. The purpose of our study was to compare coexpressed genes, by meta-analysis, of GATA3 and relate these to a similar analysis for ERalpha to determine the depth of overlap.

Results

We have used a newly described method of meta-analysis of multiple cancer studies within the O

SUBMITTER: Wilson BJ 

PROVIDER: S-EPMC2430971 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature