Effective, robust design of community mitigation for pandemic influenza: a systematic examination of proposed US guidance.

ABSTRACT:

Background

The US government proposes pandemic influenza mitigation guidance that includes isolation and antiviral treatment of ill persons, voluntary household member quarantine and antiviral prophylaxis, social distancing of individuals, school closure, reduction of contacts at work, and prioritized vaccination. Is this the best strategy combination? Is choice of this strategy robust to pandemic uncertainties? What are critical enablers of community resilience?

Methods and findings

We systematically simulate a broad range of pandemic scenarios and mitigation strategies using a networked, agent-based model of a community of explicit, multiply-overlapping social contact networks. We evaluate illness and societal burden for alterations in social networks, illness parameters,

SUBMITTER: Davey VJ 

PROVIDER: S-EPMC2432023 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature