Statin induced myopathy and myalgia: time trend analysis and comparison of risk associated with statin class from 1991-2006.

ABSTRACT:

Background

Statins are widely used as a cholesterol lowering medication, reduce cardiovascular mortality and morbidity in high risk patients; and only rarely cause serious adverse drug reactions (ADRs). UK primary care databases of morbidity and prescription data, which now cover several million people, have potential for more powerful analytical approaches to study ADRs including adjusting for confounders and examining temporal effects.

Methods

Case-crossover design in detecting statin associated myopathy ADR in 93, 831 patients, using two independent primary care databases (1991-2006). We analysed risk by drug class, by disease code and cumulative year, exploring different cut-off exposure times and confounding by temporality.

Results

Using a 12 and 26 week exposure

SUBMITTER: Molokhia M 

PROVIDER: S-EPMC2432025 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature