Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study.

ABSTRACT:

Background

Many studies have shown that the abundance level of gene expression is heritable. Analogous to the traditional genetic study, most researchers treat the expression of one gene as a quantitative trait and map it to expression quantitative trait loci (eQTL). This is 1D-trait mapping. 1D-trait mapping ignores the trait-trait interaction completely, which is a major shortcoming.

Results

To overcome this limitation, we study the expression of a pair of genes and treat the variation in their co-expression pattern as a two dimensional quantitative trait. We develop a method to find gene pairs, whose co-expression patterns, including both signs and strengths, are mediated by genetic variations and map these 2D-traits to the corresponding genetic loci. We report several ap

SUBMITTER: Sun W 

PROVIDER: S-EPMC2432080 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature