Functional importance of different patterns of correlation between adjacent cassette exons in human and mouse.

ABSTRACT:

Background

Alternative splicing expands transcriptome diversity and plays an important role in regulation of gene expression. Previous studies focus on the regulation of a single cassette exon, but recent experiments indicate that multiple cassette exons within a gene may interact with each other. This interaction can increase the potential to generate various transcripts and adds an extra layer of complexity to gene regulation. Several cases of exon interaction have been discovered. However, the extent to which the cassette exons coordinate with each other remains unknown.

Results

Based on EST data, we employed a metric of correlation coefficients to describe the interaction between two adjacent cassette exons and then categorized these exon pairs into three different group

SUBMITTER: Peng T 

PROVIDER: S-EPMC2432081 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature