Chloroquine mediated modulation of Anopheles gambiae gene expression.

ABSTRACT:

Background

Plasmodium development in the mosquito is crucial for malaria transmission and depends on the parasite's interaction with a variety of cell types and specific mosquito factors that have both positive and negative effects on infection. Whereas the defensive response of the mosquito contributes to a decrease in parasite numbers during these stages, some components of the blood meal are known to favor infection, potentiating the risk of increased transmission. The presence of the antimalarial drug chloroquine in the mosquito's blood meal has been associated with an increase in Plasmodium infectivity for the mosquito, which is possibly caused by chloroquine interfering with the capacity of the mosquito to defend against the infection.

Methodology/principal findings

In

SUBMITTER: Abrantes P 

PROVIDER: S-EPMC2432468 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature