APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.

ABSTRACT: Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

SUBMITTER: Reis A 

PROVIDER: S-EPMC2435241 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature