Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes.

ABSTRACT: Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1, a protein that is essential for repressing transcription by RNA polymerase (pol) III in Saccharomyces cerevisiae. Here we identify the functions buffering yeast cells that are unable to down-regulate transcription by RNA pol III. MAF1 genetic interactions identified in screens of non-essential gene-deletions and conditionally expressed essential genes reveal a highly interconnected network of 64 genes involved in ribosome biogenesis, RNA pol II transcription, tRNA modification, ubiquitin-dependent proteolysis and other processes. A survey

SUBMITTER: Willis IM 

PROVIDER: S-EPMC2435279 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature