Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.

ABSTRACT: Corticosterone hormones mediate the stress response and function in the survival of hippocampal neurons via activation of gluco-(GR) and mineralocorticoid (MR) receptors. Activated GR and MR couple the corticosterone signal through immediate early genes (IEGs) to the late expression of downstream genes, such as neurotrophic factors. The potential importance of IEGs in GR/MR-dependent plasticity in the brain is largely unknown. We examined the region- and time-dependent transcriptional profiles of six IEGs (c-fos, fosB, fra-1, junB, c-jun and egr-1) by in situ hybridization after acute corticosterone challenge in the hippocampus and the primary somatosensory cortex (S1). Adrenalectomized rats and subsequent hormone injections were used as a model system to eliminate interference of endogeno

SUBMITTER: Hansson AC 

PROVIDER: S-EPMC2435408 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature