Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach.

ABSTRACT:

Background

Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular target proteins. The precise mechanisms underlying calcium binding to calmodulin are still, however, quite poorly understood.

Results

In this study, we adopt a structural systems biology approach and develop a mathematical model to investigate various types of cooperative calcium-calmodulin interactions. We compare the predictions of our analysis with physiological dose-response curves taken from the literature, in order to provide a quantitative comparison of the effects of different mechanisms of cooperativity on calcium-calmodul

SUBMITTER: Valeyev NV 

PROVIDER: S-EPMC2435525 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature