Leptin and ghrelin in relation to Helicobacter pylori status in adult males.

ABSTRACT:

Context

Leptin and ghrelin, hormones involved in human energy homeostasis, are both produced in the stomach.

Objective

We sought to determine whether the presence of Helicobacter pylori affects gastric and systemic levels of leptin and ghrelin.

Design, setting, and patients

We consecutively enrolled 256 patients referred for upper endoscopy at a Veterans Affairs outpatient endoscopy center.

Outcomes

We obtained fasting serum, fundic and antral biopsies, and gastric juice. Based on histological, biochemical, and serological assays, patients were categorized as H. pylori+ or H. pylori-. Leptin and total ghrelin levels in serum, gastric biopsies, and gastric juice were determined by specific ELISAs.

Results

Of the 256 subjects, 120 were H. pylori+ and 96 we

SUBMITTER: Roper J 

PROVIDER: S-EPMC2435636 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature