On reporting results from randomized controlled trials with recurrent events.

ABSTRACT:

Background

Evidence-based medicine has been advanced by the use of standards for reporting the design and methodology of randomized controlled trials (RCT). Indeed, without this information it is difficult to assess the quality of evidence from an RCT. Although a variety of statistical methods are available for the analysis of recurrent events, reporting the effect of an intervention on outcomes that recur is an area that remains poorly understood in clinical research. The purpose of this paper is to outline guidelines for reporting results from RCTs where the outcome of interest is a recurrent event.

Methods

We used a simulation study to relate an event process and results from analyses of the gamma-Poisson, independent-increment, conditional, and marginal Cox models. We re

SUBMITTER: Kuramoto L 

PROVIDER: S-EPMC2438437 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature