Sequence information encoded in DNA that may influence long-range chromatin structure correlates with human chromosome functions.

ABSTRACT: Little is known about the possible function of the bulk of the human genome. We have recently shown that long-range regular oscillation in the motif non-T, A/T, G (VWG) existing at ten-nucleotide multiples influences large-scale nucleosome array formation. In this work, we have determined the locations of all 100 kb regions that are predicted to form distinctive chromatin structures throughout each human chromosome (except Y). Using these data, we found that a significantly greater fraction of 300 kb sequences lacked annotated transcripts in genomic DNA regions > or = 300 kb that contained nearly continuous chromatin organizing signals than in control regions. We also found a relationship between the meiotic recombination frequency and the presence of strong VWG chromatin organizing signal

SUBMITTER: Takasuka TE 

PROVIDER: S-EPMC2440353 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature