RelB-dependent stromal cells promote T-cell leukemogenesis.

ABSTRACT:

Background

The Rel/NF-kappaB transcription factors are often activated in solid or hematological malignancies. In most cases, NF-kappaB activation is found in malignant cells and results from activation of the canonical NF-kappaB pathway, leading to RelA and/or c-Rel activation. Recently, NF-kappaB activity in inflammatory cells infiltrating solid tumors has been shown to contribute to solid tumor initiation and progression. Noncanonical NF-kappaB activation, which leads to RelB activation, has also been reported in breast carcinoma, prostate cancer, and lymphoid leukemia.

Methodology/principal findings

Here we report a novel role for RelB in stromal cells that promote T-cell leukemogenesis. RelB deficiency delayed leukemia onset in the TEL-JAK2 transgenic mouse model of hum

SUBMITTER: dos Santos NR 

PROVIDER: S-EPMC2440518 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature