Perioperative celecoxib administration for pain management after total knee arthroplasty - a randomized, controlled study.

ABSTRACT:

Background

Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. We evaluated opioid-sparing effects and rehabilitative results after perioperative celecoxib administration for total knee arthroplasty.

Methods

This was a prospective, randomized, observer-blind control study. Eighty patients that underwent total knee arthroplasty were randomized into two groups of 40 each. The study group received a single 400 mg dose of celecoxib, one hour before surgery, and 200 mg of celecoxib every 12 hours for five days, along with patient-controlled analgesic (PCA) morphine. The control group received only PCA morphine for postoperative pain management. Visual analog scale (VAS) pain scores, active range of motion (ROM), total opioi

SUBMITTER: Huang YM 

PROVIDER: S-EPMC2440752 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature