Pervasive and persistent redundancy among duplicated genes in yeast.

ABSTRACT: The loss of functional redundancy is the key process in the evolution of duplicated genes. Here we systematically assess the extent of functional redundancy among a large set of duplicated genes in Saccharomyces cerevisiae. We quantify growth rate in rich medium for a large number of S. cerevisiae strains that carry single and double deletions of duplicated and singleton genes. We demonstrate that duplicated genes can maintain substantial redundancy for extensive periods of time following duplication ( approximately 100 million years). We find high levels of redundancy among genes duplicated both via the whole genome duplication and via smaller scale duplications. Further, we see no evidence that two duplicated genes together contribute to fitness in rich medium substantially beyond that o

SUBMITTER: Dean EJ 

PROVIDER: S-EPMC2440806 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature