Targeted development of registries of biological parts.

ABSTRACT:

Background

The design and construction of novel biological systems by combining basic building blocks represents a dominant paradigm in synthetic biology. Creating and maintaining a database of these building blocks is a way to streamline the fabrication of complex constructs. The Registry of Standard Biological Parts (Registry) is the most advanced implementation of this idea.

Methods/principal findings

By analyzing inclusion relationships between the sequences of the Registry entries, we build a network that can be related to the Registry abstraction hierarchy. The distribution of entry reuse and complexity was extracted from this network. The collection of clones associated with the database entries was also analyzed. The plasmid inserts were amplified and sequenced. The

SUBMITTER: Peccoud J 

PROVIDER: S-EPMC2441434 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature