Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20.

ABSTRACT: Metazoan development proceeds primarily through the regulated expression of genes encoding transcription factors and components of cell signaling pathways. One way to decipher the complex developmental programs is to assemble the underlying gene regulatory networks by dissecting the cis-regulatory modules that direct temporal-spatial expression of developmental genes and identify corresponding trans-regulatory factors. Here, we focus on the regulation of a HMX homoebox gene called mls-2, which functions at the intersection of a network that regulates cleavage orientation, cell proliferation and fate specification in the Caenorhabditis elegans postembryonic mesoderm. In addition to its transient expression in the postembryonic mesodermal lineage, the M lineage, mls-2 expression is detected

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC2441446 | biostudies-literature | 2008 May-Jun

REPOSITORIES: biostudies-literature