Individual mRNA expression profiles reveal the effects of specific microRNAs.

ABSTRACT:

Background

MicroRNAs (miRNAs) are oligoribonucleotides with an important role in regulation of gene expression at the level of translation. Despite imperfect target complementarity, they can also significantly reduce mRNA levels. The validity of miRNA target gene predictions is difficult to assess at the protein level. We sought, therefore, to determine whether a general lowering of predicted target gene mRNA expression by endogenous miRNAs was detectable within microarray gene expression profiles.

Results

The target gene sets predicted for each miRNA were mapped onto known gene expression data from a range of tissues. Whether considering mean absolute target gene expression, rank sum tests or 'ranked ratios', many miRNAs with significantly reduced target gene expression cor

SUBMITTER: Arora A 

PROVIDER: S-EPMC2441468 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature