Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development.

ABSTRACT:

Background

Zebrafish germ cells contain granular-like structures, organized around the cell nucleus. These structures share common features with polar granules in Drosophila, germinal granules in Xenopus and chromatoid bodies in mice germ cells, such as the localization of the zebrafish Vasa, Piwi and Nanos proteins, among others. Little is known about the structure of these granules as well as their segregation in mitosis during early germ-cell development.

Results

Using transgenic fish expressing a fluorescently labeled novel component of Zebrafish germ cell granules termed Granulito, we followed the morphology and distribution of the granules. We show that whereas these granules initially exhibit a wide size variation, by the end of the first day of development they becom

SUBMITTER: Strasser MJ 

PROVIDER: S-EPMC2441585 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature