Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes.

ABSTRACT:

Background

Adipocytes express inflammatory mediators that contribute to the low-level, chronic inflammation found in obese subjects and have been linked to the onset of cardiovascular disorders and insulin resistance associated with type 2 diabetes mellitus. A reduction in inflammatory gene expression in adipocytes would be expected to reverse this low-level, inflammatory state and improve cardiovascular function and insulin sensitivity. The natural products, curcumin and resveratrol, are established anti-inflammatory compounds that mediate their effects by inhibiting activation of NF-kappaB signaling. In the present study, we examined if these natural products can inhibit NF-kappaB activation in adipocytes and in doing so reduce cytokine expression.

Methods

Cytokine (TNF-al

SUBMITTER: Gonzales AM 

PROVIDER: S-EPMC2441623 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature