Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells.

ABSTRACT:

Background

Understanding the relative importance of signaling pathway components which regulate a specific cellular response is a major focus of current efforts in biology. This interest, along with the inherit complexity of these systems, is driving the development of approaches capable of providing both quantitative predictions as well as guiding the design of future experiments. Of particular interest is the establishment of methods for the analysis of cellular-level input-output signaling relationships that have been characterized over time.

Results

Work by the Alliance for Cellular Signaling (AfCS) has provided an extensive profile of ligand-induced changes in protein phosphorylation state and cytokine output response in macrophage-like RAW 264.7 cells. Using model aver

SUBMITTER: Wu Y 

PROVIDER: S-EPMC2441624 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature