AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.

ABSTRACT:

Background

The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients.

Methods

The association of DTNBP1 in the Irish Study of High Density Schizophrenia Families (ISHDSF) prompted our investigation of AKT1 for association with disease in this sample. Eight single nucleotide polymorphisms spanning AKT1 were analyzed for association with schizophrenia across four definitions of affection and according to Operational Criter

SUBMITTER: Thiselton DL 

PROVIDER: S-EPMC2441648 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature