Modelling the epidemiological impact of intermittent preventive treatment against malaria in infants.

ABSTRACT:

Background

Trials of intermittent preventive treatment against malaria in infants (IPTi) using sulphadoxine-pyrimethamine (SP) have shown a positive, albeit variable, protective efficacy against clinical malaria episodes. The impact of IPTi in different epidemiological settings and over time is unknown and predictions are hampered by the lack of knowledge about how IPTi works. We investigated mechanisms proposed for the action of IPTi and made predictions of the likely impact on morbidity and mortality.

Methods/principal findings

We used a comprehensive, individual-based, stochastic model of malaria epidemiology to simulate recently published trials of IPTi using SP with site-specific characteristics as inputs. This baseline model was then modified to represent hypotheses co

SUBMITTER: Ross A 

PROVIDER: S-EPMC2441827 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature