Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling.

ABSTRACT:

Background

Histone-modifying enzymes are essential for a wide variety of cellular processes dependent upon changes in gene expression. Histone deacetylases (HDACs) lead to the compaction of chromatin and subsequent silencing of gene transcription, and they have recently been implicated in a diversity of functions and dysfunctions in the postnatal and adult brain including ocular dominance plasticity, memory consolidation, drug addiction, and depression. Here we investigate the role of HDACs in the generation of neurons and astrocytes in the embryonic brain.

Principal findings

As a variety of HDACs are expressed in differentiating neural progenitor cells, we have taken a pharmacological approach to inhibit multiple family members. Inhibition of class I and II HDACs in develop

SUBMITTER: Shaked M 

PROVIDER: S-EPMC2441862 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature