Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology.

ABSTRACT: The ability to perform large-scale, expression-based chemogenomics on whole adult organisms, as in invertebrate models (worm and fly), is highly desirable for a vertebrate model but its feasibility and potential has not been demonstrated. We performed expression-based chemogenomics on the whole adult organism of a vertebrate model, the zebrafish, and demonstrated its potential for large-scale predictive and discovery chemical biology. Focusing on two classes of compounds with wide implications to human health, polycyclic (halogenated) aromatic hydrocarbons [P(H)AHs] and estrogenic compounds (ECs), we generated robust prediction models that can discriminate compounds of the same class from those of different classes in two large independent experiments. The robust expression signatures led

SUBMITTER: Lam SH 

PROVIDER: S-EPMC2442223 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature