The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis.

ABSTRACT:

Background

Mutations in Nek1 (NIMA-Related Kinase 1) are causal in the murine models of polycystic kidney disease kat and kat2J. The Neks are known as cell cycle kinases, but recent work in protists has revealed that in addition to roles in the regulation of cell cycle progression, some Neks also regulate cilia. In most cells, cilia are disassembled prior to mitosis and are regenerated after cytokinesis. We propose that Neks participate in the coordination of ciliogenesis with cell cycle progression. Mammalian Nek1 is a candidate for this activity because renal cysts form in response to dysfunctional ciliary signalling.

Results

Here we report that over-expression of full-length mNek1 inhibited ciliogenesis without disrupting centrosomes in the murine renal epithelial cell li

SUBMITTER: White MC 

PROVIDER: S-EPMC2442590 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature