The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains.

ABSTRACT:

Background

Novel immune-type receptor (NITR) genes are members of diversified multigene families that are found in bony fish and encode type I transmembrane proteins containing one or two extracellular immunoglobulin (Ig) domains. The majority of NITRs can be classified as inhibitory receptors that possess cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs). A much smaller number of NITRs can be classified as activating receptors by the lack of cytoplasmic ITIMs and presence of a positively charged residue within their transmembrane domain, which permits partnering with an activating adaptor protein.

Results

Forty-four NITR genes in medaka (Oryzias latipes) are located in three gene clusters on chromosomes 10, 18 and 21 and can be organized into 24 families i

SUBMITTER: Desai S 

PROVIDER: S-EPMC2442602 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature