HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer.

ABSTRACT: The HER4 receptor tyrosine kinase was the final member of the EGFR-family to be discovered. In contrast to the other three members of this receptor family which function primarily as mitogenic effectors in the breast, HER4 appears to have multiple divergent functions in the normal and malignant breast. Interestingly, the majority of HER4 activities in the breast including pregnancy induced differentiation and lactation initiation, transcriptional activation, tumor cell proliferation, growth suppression, and induction of apoptosis appear to be mediated by an independently signaling soluble HER4 intracellular domain (4ICD). The 4ICD can accumulate within the nucleus or mitochondria and subcellular localization of 4ICD in part determines the physiological response of breast cells to 4ICD acti

SUBMITTER: Jones FE 

PROVIDER: S-EPMC2442669 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature