Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.

ABSTRACT: Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Albizia gummifera led to the isolation of three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C (1-3). The structures of these new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1-3 showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.

SUBMITTER: Cao S 

PROVIDER: S-EPMC2442826 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature