AMYPdb: a database dedicated to amyloid precursor proteins.

ABSTRACT:

Background

Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of in silico methods to investigate the molecular mechanisms of their abnormal conformational changes and assembly. However, such an approach requires the collection of accurate data, which are inconveniently dispersed among several generalist databases.

Results

We therefore created a free online knowledge database (AMYPdb) dedicated to amyloid precursor proteins and we have performed large scale sequence analysis of the included data. Currently, AMYPdb integrates data on 31

SUBMITTER: Pawlicki S 

PROVIDER: S-EPMC2442844 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature