Proteomic profile of dormant Trichophyton rubrum conidia.

ABSTRACT:

Background

Trichophyton rubrum is the most common dermatophyte causing fungal skin infections in humans. Asexual sporulation is an important means of propagation for T. rubrum, and conidia produced by this way are thought to be the primary cause of human infections. Despite their importance in pathogenesis, the conidia of T. rubrum remain understudied. We intend to intensively investigate the proteome of dormant T. rubrum conidia to characterize its molecular and cellular features and to enhance the development of novel therapeutic strategies.

Results

The proteome of T. rubrum conidia was analyzed by combining shotgun proteomics with sample prefractionation and multiple enzyme digestion. In total, 1026 proteins were identified. All identified proteins were compared to those

SUBMITTER: Leng W 

PROVIDER: S-EPMC2443143 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature